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Augenzentrum AG
Fährweg 10
CH-4600 Olten
beim Kantonsspital
Haus M/Eingang West/1.OG
Tel. +41 62 206 87 37
Fax +41 62 206 87 38
Mail
info@basedow.ch

Prof Dr. med. Gottfried Rudofsky

Ärztlicher Leiter
Endokrinologie, Diabetologie und Klinische Ernährung soH

Tel. 062-311-4237
Email gottfried.rudofsky@spital.so.ch

Adresse
Solothurner Spitäler AG
Kantonsspital Olten
Baslerstrasse 150
4600 Olten
T +41 (0)62 311 41 11



Ausbildung / Bisherige Tätigkeit

2001
2003
2008
2009
2009

2010
2013


2001-2003
2003-2005

2005-2008

2009-2013
<10/2013
Staatsexamen Humanmedizin, Universität Heidelberg
Promotion zum Dr. med., Universität Heidelberg
Facharzttitel Internist
Spezialisierung Nephrologie
Venia legendi für das Fach Innere Medizin, Universität Heidelberg
Spezialisierung Endokrinologie und Diabetologie
Ausserplanmässige Professur an der Universität Heidelberg


Arzt im Praktikum, Universitätsklinikum Heidelberg
Assistenzarzt Innere Medizin und Endokrinologie, Universitätsklinikum Heidelberg
Assistenzarzt Innere Medizin und Nephrologie, Nierenzentrum Heidelberg
Oberarzt Endokrinologie, Universitätsklinikum Heidelberg
Ärztlicher Leiter für Endokrinologie, Diabetologie und Klinische Ernährung soH


Forschungsschwerpunkte

- Optimierung konservativer Ansätze zur Gewichtsreduktion und Gewichtserhaltung
- Genetische Regulatoren des Gewichts
- Rolle und Funktion des braunen Fettgewebes bei Gewichtsreduktion
  und -erhaltung
- Modulation des inflammatorischen Potentials bei Diabetes und Assoziationen
  mit diabetische Spätschäden


Publikationen

Originalarbeiten
Fischer L, Elzein Z, Bruckner T, Hünnemeyer K, Rudofsky G, Reichenberger M, Schommer K, Gutt CN, Büchler MW, Müller-Stich B. Herausforderungen beim Aufbau eines operativen Adipositaszentrums. Der Chirurg. In press

Kenngott HG, Clemens G, Gondan M, Senft J, Diener MK, Rudofsky G, Nawroth PP, Büchler MW, Fischer L, Müller-Stich BP. DiaSurg 2 trial - surgical vs. medical treatment of insulin-dependent type 2 diabetes mellitus in patients with a body mass index between 26 and 35 kg/m2: study protocol of a randomized controlled multicenter trial - DRKS00004550. Trials 14:183, 2013

Wallmeier D, Winkler JK, Woehning A, Fleming T, Huennemeyer K, Roeder E, Nawroth PP, Friederich HC, Wolfrum C, Schultz JH, Rudofsky G. Genetic modulation of the serotonergic pathway: influence on weight reduction and weight maintenance. Genes and Nutrition In press

Winkler JK, Schultz JH, Woehning A, Piel D, Gartner L, Hildebrand M, Roeder E, Nawroth PP, Wolfrum C, Rudofsky G. Effectiveness of a Low-Calorie Weight Loss Program in Moderately and Severely Obese Patients. Obes facts. In press

Wu M, Giel KE, Skunde M, Schag K, Rudofsky G, de Zwaan M, Zipfel S, Herzog W, Friederich HC. Inhibitory control and decision making under risk in bulimia nervosa and binge eating disorder. Int J Eat Disord. In press

Groener JB, Reismann P, Fleming T, Kalscheuer H, Lehnhoff D, Hamann A, Bierhaus A, Nawroth PP, Rudofsky G. C332C Genotype of Glyoxalase 1 and its Association with Late Diabetic Complications. Exp Clin Endocrinol Diabetes 121:436-439, 2013

Mrosek N, Meissburger1 B, Mataki C, Roeder E, Ukropec J, Klimes I, Gasperikova D, Nawroth PP, Rudofsky G, Auwerx, J, Schoonjans K, Wolfrum C. Transcriptional regulation of adipocyte formation by the liver receptor homologue 1 (Lrh1) – Small hetero-dimerization partner (Shp) network. Mol Metab. 2:314-23, 2013

Send A, Al-Ayyash A, Schecher S, Rudofsky G, Klein U, Schaier M, Pruszydlo MG, Witticke D, Lohmann K, Kaltschmidt J, Haefeli WE, Seidling HM. Development of a standardised knowledge-base to automatically generate individualized medication plans with drug administration recommendations. Br J Clin Pharmacol. 76 Suppl 1:37-46, 2013

Rohm M, Sommerfeld A, Strzoda D, Jones A, Sijmonsma T, Rudofsky G, Wolfrum C, Sticht C, Gretz N, Zeyda M, Leitner L, Nawroth P, Stulnig T, Diaz MB, Vegiopoulos A, Herzig S. Transcriptional co-factor TBLR1 controls lipid mobilization in white adipose tissue. Cell Metab S1550-4131, 2013

Schütt F, Bruckner T, Schäfer K, Lehnhoff D, Rudofsky G, Kasperk C, Nawroth P, Auffarth GU. Fundus screening by medical technicians. Ophthalmologe 110:154-159, 2013

Woehning A, Schultz JH, Roeder E, Moeltner A, Isermann B, Nawroth PP, Wolfrum C, Rudofsky G. The A-allele of the common FTO gene variant rs9939609 complicates weight maintenance in severe obese patients. Int J Obes 37: 135-139, 2013

Rudofsky G, Reismann P, Groener JB, Djuric Z, Fleming T, Metzner C, Grafe IA, Bierhaus A, Nawroth PP. Identical LDL-cholesterol lowering but non-identical effects on NF-κB activity: high dose simvastatin vs combination therapy with ezetimibe. Atherosclerosis 223:190-6, 2012

Winkler JK, Woehning A, Schultz JH, Brune M, Beaton N, Challa TD, Minkova S, Roeder E, Nawroth PP, Friederich HC, Wolfrum C, Rudofsky G. Taq1A polymorphism in Dopamine D2 Receptor gene complicates weight maintenance in younger obese patients. Nutrition 28:996-1001, 2012

Challa TD, Beaton N, Arnold M, Rudofsky G, Langhans W, Wolfrum C. Regulation of adipocyte formation by GLP-1/GLP-1R signalling. J Biol Chem 287:6421-6430, 2012

Meissburger B, Ukropec J, Roeder E, Beaton N, Geiger M, Teupser D, Civan B, Langhans W, Nawroth PP, Gasperikova D, Rudofsky G, Wolfrum C. Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma. EMBO Mol Med 3: 637-51, 2011

Rudofsky G, Tsioga M, Reismann P, Leowardi C, Kopf S, Grafe IA, Nawroth PP, Isermann B. Transient Hyperthyroidism after Surgery for Secondary Hyperparathyroidism: A Common Problem. Eur J Med Res 16:375-80, 2011

Meissburger B, Stachorski L, Röder E, Rudofsky G, Wolfrum C. Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans. Diabetologia 54:1468-79, 2011

Wang H, Madhusudhan T, He T, Hummel B, Schmidt S, Vinnikov IA, Shahzad K, Kashif M, Muller-Krebs S, Schwenger V, Bierhaus A, Rudofsky G, Nawroth PP, Isermann B. Low but sustained coagulation activation ameliorates glucose induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy. Blood 117:5231-42, 2011

Rudofsky G, Roeder E, Merle T, Hildebrand M, Nawroth PP, Wolfrum C. Weight Loss Improves Endothelial Function Independently of ADMA Reduction in Severe Obesity. Horm Metab Res 43:343-8, 2011

Kasperk C, Grafe IA, Schmitt S, Nöldge G, Weiss C, Da Fonseca K, Hillmeier J, Libicher M, Sommer U, Rudofsky G, Meeder PJ, Nawroth P. Three-year outcomes after kyphoplasty in patients with osteoporosis with painful vertebral fractures. J Vasc Interv Radiol 21:701-9, 2010

Djuric Z, Sharei V, Rudofsky G, Morcos M, Li H, Hammes HP, Nawroth PP, Bierhaus A, Humpert PM, Jonas JB. Association of Homozygous SDF-1 3´A Genotype with Proliferative Diabetic Retinopathy. Acta Diabetol 47:79-82, 2010

Rudofsky G Jr, Schlotterer A, Reismann P, Grafe IA, Tafel J, Morcos M, Humpert PM, Nawroth PP, Bierhaus A, Hamann A. The -174G>C IL-6 gene promoter polymorphism and diabetic microvascular complications. Horm Metab Res 41: 308-13, 2009

Kolb A, Rieder S, Born D, Giese NA, Giese T, Rudofsky G, Werner J, Büchler MW, Friess H, Esposito I, Kleeff J. Glucagon/insulin ratio as a potential biomarker for pancreatic cancer in patients with new-onset diabetes mellitus. Cancer Biol Ther 8:1527-1533, 2009

Rudofsky G Jr, Schlotterer A, Nawroth PP, Bierhaus A, Hamann A: Comment on: Lin et al. (2007) SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes: Diabetes 56: 1177-1180. Diabetes 56: e11, 2007

Morcos M, Schlotterer A, Sayed AA, Kukudov G, Oikomonou D, Ibrahim Y, Pfisterer F, Schneider J, Bozorgmehr F, Rudofsky G Jr, Schwenger V, Kientsch-Engels R, Hamann A, Zeier M, Dugi K, Yard B, Humpert PM, Woude F, Nawroth PP, Bierhaus A. Rosiglitazone Reduces Angiotensin II and Advanced Glycation End Product-dependent Sustained Nuclear Factor-kappaB Activation in Cultured Human Proximal Tubular Epithelial Cells. Horm Metab Res 40: 752-759, 2008

Rudofsky G Jr, Schlotterer A, Humpert PM, Tafel J, Morcos M, Nawroth PP, Bierhaus A, Hamann A. A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with type 1 diabetes. Exp Clin Endocrinol Diab 116: 14-17, 2008

Buchbinder S, Rudofsky G Jr, Humpert PM, Schilling T, Zorn M, Bierhaus A, Nawroth PP: The DG10S478 Variant in the TCF7L2 Gene is not Associated with Microvascular Complications in Type 2 Diabetes. Exp Clin Endocrinol Diabetes 116: 211-214, 2008

Grafe IA, Baier M, Nöldge G, Weiss C, Da Fonseca K, Hillmeier J, Libicher M, Rudofsky G, Metzner C, Nawroth P, Meeder PJ, Kasperk C. Calcium-phosphate and polymethylmethacrylate cement in long-term outcome after kyphoplasty of painful osteoporotic vertebral fractures. Spine 33: 1284-1290, 2008

Rudofsky G Jr, Reismann P, Grafe IA, Konrade I, Djuric Z, Tafel J, Buchbinder S, Zorn M, Humpert PM, Hamann A, Morcos M, Nawroth PP, Bierhaus A. Improved Vascular Function upon Pioglitazone Treatment in Type 2 Diabetes is not Associated with Changes in Mononuclear NF-kappaB Binding Activity. Horm Metab Res 39: 665-671, 2007

Rudofsky G Jr, Schrödter A, Voron`ko OE, Schlotterer A, Humpert PM, Tafel J, Nawroth PP, Bierhaus A, Hamann A. Promoter polymorphisms of UCP1, UCP2, and UCP3 are not associated with diabetic microvascular complications in type 2 diabetes. Horm Metab Res 39: 306-309, 2007

Humpert PM, Kopf S, Djuric Z, Laine K, Korosoglou G, Rudofsky G Jr, Hamann A, Morcos M, von Eynatten M, Nawroth PP, Bierhaus A. Levels of three distinct p75 neurotrophin receptor forms found in human plasma are altered in type 2 diabetic patients. Diabetologia 50: 1517-1522, 2007

Humpert PM, Djuric Z, Kopf S, Rudofsky G, Morcos M, Nawroth PP, Bierhaus A. Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes. Cardiovasc Diabetol 6: 9, 2007

Rudofsky G Jr, Schroedter A, Schlotterer A, Voron`ko OE, Schlimme M, Tafel J, Isermann BH, Humpert PM, Morcos M, Bierhaus A, Nawroth PP, Hamann A. Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes. Diabetes Care 29: 89-94, 2006

Schiekofer S, Franke S, Andrassy M, Chen J, Rudofsky G, Schneider JG, von Eynatten M, Wendt T, Morcos M, Kientsch-Engel R, Stein G, Schleicher E, Nawroth PP, Bierhaus A. Postprandial mononuclear NF-kappaB activation is independent of the AGE-content of a single meal. Exp Clin Endocrinol Diabetes 114: 160-167, 2006

Humpert PM, Battista MJ, Lammert A, Reismann P, Djuric Z, Rudofsky G Jr, Zorn M, Morcos M, Hammes HP, Nawroth PP, Bierhaus A. Association of stromal cell-derived factor 1 genotype with diabetic foot syndrome and macrovascular disease in patients with type 2 diabetes. Clin Chem 52: 1206-1208, 2006

Rudofsky G, Schlimme M, Schlotterer A, von Eynatten M, Reismann P, Tafel J, Grafe I, Morcos M, Nawroth PP, Bierhaus A, Hamann A. No association of the 94 T/G polymorphism in the adiponectin gene with diabetic complications. Diabetes Obes Metab 7: 455-459, 2005

Humpert PM, Neuwirth R, Battista MJ, Voronk´o O, von Eynatten M, Konrade I, Rudofsky G Jr., Wendt Th, Hamann A, Morcos M, Nawroth PP, Bierhaus A. Insulin therapy triggers mobilization of adult progenitor cells in diabetes type 2 partly depending on the SDF-1genotype. Diabetes Care 28: 934-936, 2005

Rudofsky G Jr, Reismann P, Witte S, Humpert PM, Isermann B, Chavakis T, Tafel J, Nosikov VV, Hamann A, Nawroth P, Bierhaus A. Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes. Diabetes Care 27: 179-183, 2004

Rudofsky G Jr, Chen J, Isermann B, Schilling T, Schiekofer S, Andrassy M, Schneider J, Morcos M, Hamann A, Humpert PM, Sayed AAR, Witte S, Renn W, Pfohl M, Nosikov V, Schleicher E, Häring HU, Rudofsky G sen., Ritz E, Nawroth PP, Bierhaus A. A 63 bp deletion in the promoter of RAGE correlates with a decreased risk for nephropathy in patients with diabetes type 2. Exp Clin Endocrinol Diab 112: 135-141, 2004

Reismann P, Lichy Ch, Rudofsky G Jr., Humpert PM, Genius J, Dong-Si T, Dörfer Ch, Grau AJ, Hamann A, Hacke W, Nawroth PP, Bierhaus A. Lack of association between polymorphisms of the Toll-like receptor 4 gene and cerebral ischemia. J Neurol 251: 853-858, 2004

von Eynatten M, Schneider G, Humpert PM, Rudofsky G, Schmidt N, Barosch P, Hamann A, Morcos M, Kreuzer J, Bierhaus A, Nawroth PP, Dugi KA. Decreased plasma lipoprotein lipase in hypoadiponectinemia: an association independent of systemic inflammation and insulin resistance. Diabetes Care 27: 2925-2959, 2004

Rudofsky G Jr., Reismann P, Schiekofer S, Petrov D, von Eynatten M, Humpert PM, Isermann B, Müller-Hoff C, Thai T-P, Lichtenstein S, Bärtsch U, Hamann A, Nawroth PP, Bierhaus A. Reduction of postprandial hyperglycemia in patients with type 2 diabetes reduces NF-κB activation in PBMCs. Horm Metab Res 36: 630-638, 2004

Schiekofer S, Andrassy M, Chen J, Rudofsky G, Schneider J, Wendt T, Stefan N, Humpert P, Fritsche A, Stumvoll M, Schleicher E, Haring HU, Nawroth PP, Bierhaus A. Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor kappaB in PBMCs. Diabetes 52: 621-633, 2003

Bierhaus A, Wolf J, Andrassy M, Rohleder N, Humpert PM, Petrov D, Ferstl R, von Eynatten M, Wendt Th, Rudofsky G, Joswig M, Morcos M, Schwaninger M, McEwen B, Kirschbaum C, Nawroth PP. A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci 100: 1920-1925, 2003

Schiekofer S, Rudofsky G Jr, Andrassy M, Schneider J, Chen J, Isermann B, Kanitz M, Elsenhans S, Heinle H, Balletshofer B, Haring HU, Schleicher E, Nawroth PP, Bierhaus A. Glimepiride reduces mononuclear activation of the redox-sensitive transcription factor NF-κB. Diabetes Obes Metabol 5: 251-261, 2003

Humpert PM, Isermann B, Rudofsky G, Ziegler R, Bierhaus A, Ritz E, Nawroth PP. The 20210 G to A prothrombin polymorphism and late complications in type 1 diabetes mellitus. Thromb Haemost 81:164, 1999

Übersichtsarbeiten
Rudofsky G, Ruessmann HJ, Siegmund T. SGLT2 inhibition: an effective therapeutic approach in the treatment of diabetes mellitus? DMW 138:1172-1177, 2013

Oikonomou D, Rudofsky G. Kidney and eye in diabetes: diagnosis and therapy, useful aspects for general practitioners. MMW Fortschr Med 154:71-4, 2012

Nawroth PP, Rudofsky G, Humpert P. Have we understood diabetes? New tasks for diagnosis and therapy. Exp Clin Endocrinol Diabetes 118:1-3, 2010

Isermann B, Bierhaus A, Humpert P, Rudofsky G, Chavakis T, Ritzel R, Morcos M, Wendt Th Hamann A, Nawroth PP. AGE-RAGE: eine Hypothese oder ein Mechanismus? Herz 29: 504-509, 2004

Bierhaus A, Humpert PM, Rudofsky G, Wendt Th, Morcos M, Hamann A, Nawroth PP. New treatments for diabetic neuropathy - pathogenetically oriented treatment. Curr Diab Rep 3, 452-458, 2003


Fallberichte
Groener JB, Lehnhoff D, Piel D, Nawroth PP, Schanz J, Rudofsky G. Subcutaneous application of levothyroxine as successful treatment option in a patient with malabsorption. Am J Case Rep 14: 48-51, 2013

Schanz J, Rudofsky G, Runz H, Rath T. A deaf mother and son with diabetes and renal failure. Clin Kidney J 5: 137-139, 2012

Schanz J, Flux K, Kircher C, Tsioga M, Hartschuh W, Nawroth PP, Rudofsky G. Granulomatous inflammation of the skin and lymph nodes with systemic hypercalcemia after cosmetic treatment with liquid silicone. Med Sci Mon 18:CS5-7, 2012

Rudofsky G Jr, Villalobos M, Zorn M, Maimer A, Schaier M, Morcos M, Zeier M, Nawroth PP, Isermann B. Diagnostical relevance of cystatin C measurement in patients with pseudohypercreatininaemia. Kidney Int 77:371-2, 2010

Rudofsky G Jr, Grafe IA, Metzner C, Leowardi C, Fohr B. Transient thyrotoxicosis after parathyroidectomy without underlying thyroid disease. Med Sci Mon 15: CS41-3, 2009

Wildemann B, Rudofsky G Jr, Kress B, Jarius S, Konig F, Schwenger V. The tumor-necrosis-factor-associated periodic syndrome, the brain, and tumor-necrosis-factor-alpha antagonists. Neurology 68: 1742-1744, 2007

Rudofsky G Jr, Hoffmann F, Muller K, Filser M, Lohse P, Beimler J, Schwenger V. A nephrotic patient with tumour necrosis factor receptor-associated periodic syndrome, IgA nephropathy and CNS involvement. Nephrol Dial Transplant 21:1109-1112, 2006


Buchbeiträge
Bierhaus A, Humpert P, Rudofsky G, Chavakis T, Wendt T, Hamann A, Nawroth PP: Inflammation. In: Meinertz, Rösen, Schömig, Tschöpe, Ziegler (Hrsg.): Diabetes und Herz. Springer-Verlag, 55-64, 2004